Effect of Vitamin D Supplementation in Patients of Moderate Asthma Undergoing Treatment with Inhaled Corticosteroids

Background: Vitamin D is an essential nutrient with significant immunomodulatory effects. There is potential for a protective role of vitamin D against etiopathogenesis of asthma and morbidity. This study evaluated the effect of vitamin D supplementation in patients with moderate asthma. Aims and Objectives: To evaluate the effect of vitamin D supplementation on lung function improvement in patients of moderate asthma undergoing treatment with inhaled corticosteroids. Materials and Methods: An interventional prospective study. A total of 60 patients of moderate asthma were enrolled in the study and randomly divided into two groups of 30 patients each. Group A: placed on steroid based treatment regimen (formoterol 6 µg + budesonide 200 µg) + Vitamin D supplementation [60,000IU/week for 8 consecutive weeks]. Group B: placed on steroid based treatment regimen (formoterol 6 µg + budesonide 200 µg) only, as control. The enrolled patients were followed up for 12 weeks and assessed for various parameters of disease severity, asthma control and improvement in lung function by using asthma control test [ACT] questionnaire and Pulmonary function tests (spirometry). Collected data was analyzed using available statistical software [spss ver 20.0]. Results: Statistically significant changes (P