403. Glucocorticoid-related damage assessed with glucocorticoid toxicity index (GTI) in patients with Takayasu's arteritis

Background/ Objectives: Glucocorticoids (GCs) are the mainstay treatment for Takayasu’s arteritis (TAK). However, GC-related toxicity still remains a major concern. In this study we aimed to evaluate GC-associated damage in TAK patients with glucocorticoid toxicity index (GTI) which was developed to assess GC-related toxicity. Methods: Patients followed in Marmara University Hospital Vasculitis Clinic with a diagnosis of TAK and receiving GC treatment were enrolled in the study. Damage was assessed with GTI under the headings: body mass index (BMI), glucose tolerance, blood pressure, lipids, bone density, steroid myopathy, skin toxicity, neuropsychiatric toxicity, infection, endocrine, gastrointestinal, musculoskeletal, ocular domains. Total GTI score range was defined between −36 and 439. Results: A total of 57 (F/M: 53/4) TAK patients were included. Mean age was 44.3±12.5 years and cumulative GC dose 11.1±7.2 grams. After mean 82.8±53.8 months of GC treatment, mean GTI score was found to be 51.5±52.4. GTI score was similar between genders (Total GTI: women vs men: 50.2±52.0 vs 37.2±11.7, p=0.88). Total GTI score correlated with age (r=0.32, p=0.014), cumulative GC dose (r=0.34, p=0.017) and duration of GC treatment (r=0.27, p=0.041). Conclusions: GC-related toxicity was related to cumulative dose and duration of the GC treatment in our study. GTI is a useful tool to evaluate GC-related toxicity and can be chosen both for clinical studies and routine practice to assess long-term GC-associated damage. Disclosures: Non