A REVIEW ON INTRANASAL NANOEMULSION BASED BRAIN TARGETING DRUG DELIVERY SYSTEM

The major role of blood–brain barrier (BBB) is to protect the brain from toxic substance. It does not allow therapeutic agents to enter. The nasal administration of drugs via nose-to-brain pathway allows direct drug targeting into the brain and avoids the first-pass effect. Through the nasal route the drug can enter the brain directly. Nasal delivery has become area of interest as it has advantages as ease of administration and non-invasiveness. It avoids hepatic first-pass metabolism and shows efficient absorption across the permeable nasal mucosa which confirms its selection over other traditional routes like parenteral delivery. Thus nasal delivery has many applications for local, direct nose-to-brain and mucosal vaccine delivery systemic. Selecting nanoemulsions for carrying drug is said to be a promising approach. For a drug to show its effect it should have a right route of administration which provides a right channel to reach the target they require to be suitably protected in the biological milieu till they are delivered to the site of action. This review focuses on the current situation in the use of nanoemulsions for targeting the Brain. Nanoemulsions for nasal use appear to be non-invasive and safe for brain targeting in order to treat diseases. Keywords: Blood-Brain Barrier, Brain targeting, Nanoemulsion, Nasal