Spectral and kinetic studies of thermal decomposition of complexes of biologically active glutathione with ZnII and CdII ions

Department of Chemistry, University of Delhi, Delhi-110 007, India E-mail : bibheshksingh@yahoo.co.in Fax : 91-766-6250 Manuscript received 6 June 2005 The ZnII and CdII complexes of reduced glutathione (GSH) of general composition [M(L)(X)].nH2O (where LH2 = GSH; X = CI-, NO-3/CH3CO-2, and n = 1-2) have been synthesized and characterized by elemental analysis, infrared spectra, electronic spectra and thermal studies. The complexes were found to be monomer and involved coordination through cystein sulphur and carboxylate oxygen giving tetrahedral geometry. From thermogravimetric (TG) studies, order of the reaction, mass loss and apparent activation energy have been calculated and from differential thermal analytical studies, heat of reaction has been measured. Thermodynamic activation parameters have been calculated