ANTIDIABETIC ACTIVITY OF ETHANOL EXTRACT OF SONI LEAVES (DILLENIA CELEBICA HOOGLAND.) ON BLOOD GLUCOSE LEVELS AND PANCREATIC HISTOLOGY OF MALE WISTAR RATS GLUCOSE-INDUCED

Objective: Determine the potential, effectiveness and histology of pancreatic organs of wistar male rats with type II diabetes after glucose induction by giving ethanol extract of soni leaves (Dillenia celebica Hoogland.). Method: Experimental with pre-post test randomized control group design. One-Way Anova Statistics to see a decrease and percent decrease in blood glucose levels. The histology of the pancreatic organs is based the number of endocrine cells the islet of Langerhans using a microscope. Diabetes mellitus modeling by oral glucose-induced dose 20g/kgbw. The rats were divided into 6 groups, namely Normal Control, Negative Control, Positive Control and Group given ethanol extract of Soni leaves at a dose 29,78 mg/kgbw, 59,57 mg/kgbw, 120,74 mg/kgbw, respectively. Results: Ethanol extract of soni leaves has the potential as antidiabetic which was significantly different (p˂0.05) to the negative control group and at a dose 120.74 mg/kgbw has the same effectiveness as glibenclamide (p