PREPARATION AND EVALUATION OF IN SITU GELLING MICONAZOLE NITRATE LIQUID VAGINAL SUPPOSITORY

The key purpose of this study was to prepare and evaluate of in situ gelling Miconazole nitrate liquid vaginal suppository for fungal infection. In situ gelation is a process of gel formulation at the site of application, in which a drug product formulation that exists as a liquid has been transformed into gel upon contact with body fluid or at body temperature. To solve the problem of conventional solid suppositories it would be desirable to develop a liquid suppository which forms a gel at body temperature with suitable gel strength not to be leaked out from vagina after administration and with a suitable bioadhesive force. The liquid vaginal suppository was prepared by cold method using as Poloxamer 407 & 188 as thermo reversible polymer and HPMC, Carbopol 934 and Sodium alginate as mucoadhesive polymer. Liquid suppository was prepared by different combinations of drug and excipients. Formulation was evaluated in terms of pH, Gelation temperature, Gel strength, Mucoadhesive property, Drug content estimation and in vitro drug release etc. Results indicated that HPMC based liquid suppository gave better gelation temperature than others and it was observed that the increased in concentration of HPMC shows decreased in gel strength, mucoadhesive property and drug release of formulation