A PROSPECTIVE OBSERVATIONAL STUDY ON DRUG UTILISATION OF ANTITUBERCULAR DRUGS AND ITS ADHERENCE AT TERTIARY CARE TEACHING HOSPITAL

Aims and Objectives: To determine whether the prescription is as per WHO standard drug regimen for Tuberculosis management and to assess the adherence of the patient's to prescribed drug regimen. Materials and Methods: A Prospective observational study carried out in a tertiary care teaching hospital for a period of six-month. Study carried out in department of General Medicine and Outpatient Department (TB centre). Subjects of >12 yr. age groups with tubercular infection were enrolled in the study. Patients with severe comorbid conditions, pediatric patients (11 and patients with low adherence to treatment were 28 with 5-8 MMAS score. In Present Study, 75 patients were associated with out adverse drug event (ADE) were as 25 patients were associated with ADE. Adverse Drug Event reported were mild which includes nausea, vomiting (25%), and abdominal pain (14%).Major ADR’s reported were in few patients including Hepatotoxicity, Isoniazid Neurotoxicity and Anaemia. Conclusion: All the prescriptions were found to be as per WHO standard drug regimen for TB management. Tuberculosis was observed more in adults, predominantly males. HTN & DM was most common comorbidity in TB patients. Newly diagnosed TB cases were more than known cases. Category I drug regimen was given to 81% of patients as majority of cases collected were new cases so first CAT-I are prescribed. & Category II drug regimen was given to 22% of patients. Significant differences was observed in knowledge assessment of patients on the data collected pre & post counselling. Assessment of medication adherence is made by MMAS scale questionnaire which resulted in improvement of patient compliance. Keywords: adherence, risk factor, DOTS Therapy, Pulmonary Tuberculosis ,Extra Pulmonary Tuberculosis, MMAS (Morisky Medication Adherence Scale), ADR