An Observational Cross Sectional Study to Evaluate the Effect of Thyroid Hypo Function on Serum Creatinine and Serum Uric Acid Levels to Assess the Renal Status in an Urban Hypothyroid Female Population of Reproductive Age Group in Eastern India

Background: Thyroid disorders are the most common worldwide and also in India. It is well documented that renal status such as elevated serum creatinine and serum uric acid levels are associated with hypothyroid state of the body. Aims: To investigate the effect of hypothyroid state on Serum Creatinine and Serum Uric acid levels in an urban female hypothyroid population of reproductive age group in Eastern India. Materials & methods: This present observational cross sectional study was conducted on 200 hypothyroid subjects in Burdwan Medical College for a period of 12 months after taking Institutional Ethical Clearance.100 controls were taken for the study. Serum TSH, FT4, Creatinine and Uric acid levels were estimated. The subjects were age matched. The computer software SPSS, version 16.0 was used for analyzing data. Results: 200 hypothyroid subjects were enrolled for the study.48 hypothyroid patients were with increased Serum creatinine level (24%)and 43 with increased serum uric acid level(21.5%) Significant difference was observed between control and hypothyroid subjects for mean TSH (P<0.0001), mean FT4(P<0.0001),mean Creatinine (P<0.0001) and mean Uric acid(P<0.0001). No significant difference of age was found between two groups. Serum creatinine level was positively correlated with TSH (R=0.662, P<0.00001)) and negatively correlated with Sr. FT4(R= - 0.273,P=0.000092). Also we found a positive correlation between serum uric acid and TSH(R=0.669, P