Trade-offs between traits are present across different levels of biological systems and ultimately reflect constraints imposed by physicochemical laws and the structure of underlying biochemical networks. Yet, mechanistic explanation of how trade-offs between molecular traits arise and how they relate to optimization of fitness-related traits remains elusive. Here, we introduce the concept of relative flux trade-offs and propose a constraint-based approach, termed FluTOr, to identify metabolic reactions whose fluxes are in relative trade-off with respect to an optimized fitness-related cellular task, like growth. We then employed FluTOr to identify relative flux trade-offs in the genome-scale metabolic networks of Escherichia coli, Saccharo...
MOTIVATION: Genome-scale metabolic networks can be modeled in a constraint-based fashion. Reaction s...
Motivation: Genome-scale metabolic networks can be modeled in a constraint-based fashion. Reaction s...
High-throughput data generation and genome-scale stoichiometric models have greatly facilitated the ...
Trade-offs between traits are present across different levels of biological systems and ultimately r...
Trade-offs between traits are present across different levels of biological systems and ultimately r...
Although the network topology of metabolism is well known, understanding the principles that govern ...
Although the network topology of metabolism is well known, understanding the principles that govern ...
Although the network topology of metabolism is well known, understanding the principles that govern ...
Although the network topology of metabolism is well known, understanding the principles that govern ...
Although the network topology of metabolism is well known, understanding the principles that govern ...
<div><p>Motivation</p><p>Genome-scale metabolic networks can be modeled in a constraint-based fashio...
Motivation: Genome-scale metabolic networks can be modeled in a constraint-based fashion. Reaction s...
Motivation: Genome-scale metabolic networks can be modeled in a constraint-based fashion. Reaction s...
High-throughput data generation and genome-scale stoichiometric models have greatly facilitated the ...
<div><p>High-throughput data generation and genome-scale stoichiometric models have greatly facilita...
MOTIVATION: Genome-scale metabolic networks can be modeled in a constraint-based fashion. Reaction s...
Motivation: Genome-scale metabolic networks can be modeled in a constraint-based fashion. Reaction s...
High-throughput data generation and genome-scale stoichiometric models have greatly facilitated the ...
Trade-offs between traits are present across different levels of biological systems and ultimately r...
Trade-offs between traits are present across different levels of biological systems and ultimately r...
Although the network topology of metabolism is well known, understanding the principles that govern ...
Although the network topology of metabolism is well known, understanding the principles that govern ...
Although the network topology of metabolism is well known, understanding the principles that govern ...
Although the network topology of metabolism is well known, understanding the principles that govern ...
Although the network topology of metabolism is well known, understanding the principles that govern ...
<div><p>Motivation</p><p>Genome-scale metabolic networks can be modeled in a constraint-based fashio...
Motivation: Genome-scale metabolic networks can be modeled in a constraint-based fashion. Reaction s...
Motivation: Genome-scale metabolic networks can be modeled in a constraint-based fashion. Reaction s...
High-throughput data generation and genome-scale stoichiometric models have greatly facilitated the ...
<div><p>High-throughput data generation and genome-scale stoichiometric models have greatly facilita...
MOTIVATION: Genome-scale metabolic networks can be modeled in a constraint-based fashion. Reaction s...
Motivation: Genome-scale metabolic networks can be modeled in a constraint-based fashion. Reaction s...
High-throughput data generation and genome-scale stoichiometric models have greatly facilitated the ...