Cardiac manifestations of multisystem inflammatory syndrome

Nowakowska Izabela, Osiejewska Aleksandra, Grądzik Anna, Mikut Karolina, Kudan Małgorzata, Wojtachnio Dominika, Bartoszewicz Jakub, Gorajek Anna. Cardiac manifestations of multisystem inflammatory syndrome. Journal of Education, Health and Sport. 2022;12(8):501-508. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.08.052 https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.08.052 https://zenodo.org/record/6991879 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2022; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 29.07.2022. Revised: 07.08.2022. Accepted: 15.08.2022. Cardiac manifestations of multisystem inflammatory syndrome Izabela Nowakowska1, Aleksandra Osiejewska2, Anna Grądzik2, Karolina Mikut3, Małgorzata Kudan4, Dominika Wojtachnio2, Jakub Bartoszewicz2, Anna Gorajek4 Wolski Hospital Dr. Anna Gostyńska, 01-2011, Warsaw, Poland University Clinical Center, Medical University of Warsaw, 02-097, Warsaw, Poland Collegium Medicum Nicolaus Copernicus University, 85-067, Toruń, Poland Central Clinical Hospital of the Ministry of Interior and Administration, 02-507, Warsaw, Poland Corresponding author: Izabela Nowakowska, iza.nowakowska77@gmail.com ORCID ID and e-mail: Izabela Nowakowska: https://orcid.org/0000-0002-3729-3359; iza.nowakowska77@gmail.com Aleksandra Osiejewska: https://orcid.org/0000-0002-1729-9905; aleksandraosiejewska@gmail.com Anna Grądzik: https://orcid.org/0000-0002-8457-5172; anna.gradzik123@gmail.com Karolina Mikut: https://orcid.org/0000-0001-7022-581X; karolina.mikut@gmail.com Małgorzata Kudan: https://orcid.org/0000-0001-6463-6735; malgorzata.kudan@gmail.com Dominika Wojtachnio: https://orcid.org/0000-0002-1536-8268; wojtachnio.d@gmail.com Jakub Bartoszewicz: https://orcid.org/0000-0003-1775-5648; kuba.bartoszewicz123@gmail.com Anna Gorajek: https://orcid.org/0000-0002-8043-2246; agorajek@vp.pl Key words: MIS-C; multisystem inflammatory syndrome; SARS-CoV-2; COVID-19; coronary abnormalities. Introduction and purpose: Multisystem inflammatory syndrome (MIS) in children and adolescents is an excessive inflammatory response syndrome after storage of COVID-19, which can lead to serious complications. The course of the disease may vary from mild to requiring intensive therapy. In our review, we try to draw attention to the importance of cardiological complications and present the currently used treatment. In medical professionals vigilant should be increased in order to early recognize this disease, and to be alert to the need for early cardiological evaluation and follow-up. Description of the state of knowledge: MIS can cause myocardial dysfunction, shock, coronary artery lesions, pericardial effusion, valvulitis, and electrophysiological abnormalities. Patients may require intensive medical care, careful fluid therapy, the use of pressor amines and, in rare cases, extra corporeal membranę oxygenation (ECMO). Coronary aneurysms are the most important long-term complication of MIS. They occur in up to 25% of patients. Most abnormalities are retreated within 2-3 months. MIS has a good prognosis with a mortality rate of 2%. : Cardiac complications, although serious, rarely require urgent intervention. Patients with diagnosed dilatation of the coronary arteries or aneurysm require intensive medical review in the initial period of recovery. The control must include a medical examination, ECG, ECHO and evaluation of markers of myocardial damage. Patients who have undergone MIS should be released from physical education for at least 6 weeks or until the changes in the coronary arteries disappear. The lesions resolve spontaneously in 2-3 months in most patients and do not recur, suggesting the possibility of waiving long-term patient follow-up