EVALUATION OF PROGESTERONE AND PROGESTERONE RECEPTOR GENE PROGINS POLYMORPHISM IN THE DEVELOPMENT OF SOME FORMS OF PREMENSTRUAL SYNDROME

One of the most common neuroendocrine syndromes in gynecology is premenstrual syndrome (PMS). The article is devoted to study of pro-gesterone level and frequency of polymorphic variants T1T2 of progesterone receptor gene PROGINS, as well as their possible relationship in patients with various forms of PMS. The object of the study were 50 women of reproductive age with diagnosis of PMS, including 25 women with edematous form of the disease, 25 – with neuropsychical form. Mild form of disease had 25 women, severe form – also 25 persons. Control group consisted of 25 women without diagnosis of PMS. Progesterone level was determined in blood serum twice in the first and second phase of menstrual cycle. Polymorphism T1T2 of progesterone gene receptor PROGINS was studied using polymerase chain reaction. We found hypoprogesteronemia of luteal phase of menstrual cycle in women with PMS, especially pronounced in persons with edematous and severe forms of the disease (p