GLUTATHIONE AND ITS EFFECTS ON VARIOUS SKIN CELLS: AN OVERVIEW

Glutathione (GSH) is a ubiquitous tri-peptide in body cells. Beside many ascribed biological effects such as antioxidant and scavenging various free radicals, it plays an important role in prevention of ultraviolet-associated melanomas and premature skin aging. As a cosmeceutical, it has skin whitening effect via three possible mechanisms. Moreover, GSH affects keratinocytes and fibroblasts and accelerates angiogenesis which finally develop wound healing process. Keywords: Glutathione, GSH, GSSG, Antioxidant, Oxidative stress, Melanocyte, Melanogenesis, Keratinocyte, Wound healin