Analysis and treatment results of spinal Metastases; ten years experience of Alexandria clinical oncology department

ABSTRACT Background: This study attempted to review the medical records of all patients with spinal bone metastases presented to Alexandria Clinical Oncology and Nuclear Medicine Department (ACOD), Alexandria Main University Hospital during the period from January 2003 to December 2012. Patients and Methods: A total of 350 patients were included in this study. Medical records were retrospectively reviewed and data were collected as regard demographic data, medical history, Clinical data, Investigations and diagnostic work up, treatment modalities and treatment outcomes. Results: we observed that the origin of the tumor in the majority of cases was breast cancer (31.1%), followed by prostate cancer 17.7% then multiple myeloma 17.1%.The female patients presented with the highest percentage 60.9%.performance status according Eastern Cooperative Oncology Group ( ECOG) score was 0-2 in 58% of patients. The majority of patients were complaining of pain (98.6%). A considerable percentage of cases presented with symptoms of spinal cord compression (30%). Improvement regarding pain after treatment with radiotherapy was reported in (42.6%) of patients. Motor function improvement was (89.7%) at 8 weeks for patients presented with paresis and treated early. Type of primary tumor was the most significant prognostic factor (HR=6.873 and 4.431, P