Studies in the Synthesis of Anticancer Agents : Part V1 : Nitrogen Mustards of Quinoline Derivatives

Chemistry Department, Faculty of Science, M. S. University of Baroda, Baroda-390 002 Manuscript received 4 December 1978, revised 29 August 1979, accepted 25 October 1979 p-[N,N-bis(2-Chloroethyl)-amino]benzaldehyde on condensation with hydrazide derivatives of 2-(4'-carboxyphenyl amino)-4-methyl quinolines, 2-(2'-carboxy phenyl amino)-4-methyl quinolines, 4-(4'-carboxy phenyl amino)-2-methyl quinolines, 4-(2'- carboxy phenyl amino)-2-methyl quinolines gave nitrogen mustards (IIa), (IIb), (IlIa) and (lIIe), respectively. These compounds were tested for anticancer activity against Rat Walker 256 carcinosarcoma