Forensic Diagnosis of Acute Myocardial Infarction: Application of Mass Spectrometry

Making a precise diagnosis of sudden death due to endogenous acute myocardial infarction in autopsy can be difficult, because histologic myocardial changes and other clinical data are limited. Here, we review previous studies of acute myocardial infarction for pathologic diagnosis using triphenyltetrazolium chloride staining and immunohistochemistry. Further, we introduce our method of forensic examination by mass spectrometry and a novel promising biomarker, SORBS2 for diagnosis of acute lethal cardiac infarction