PRELIMINARY STUDIES ON HEPATOPROTECTIVE ACTIVITY OF LIMONIA ACIDISSIMA AND CLITORIA TERNATAEA IN CARBON TETRA CHLORIDE INDUCED EXPERIMENTAL RATS

Objective: To evaluate the hepatoprotective activity of Limonia acidisssima leaves (LAL) and flowers of Clitoria ternatae (CTF) in experimental animals. Materials and Methods: The leaves and flowers of the selected plant were shade dried and the plant extract was prepared by using soxhlet apparatus using the solvent ethanol at constant temperature and it was used for the invivo work. Biochemical parameters like bilirubin, albumin, total protein, transaminase, phosphatase and LPO were tested in carbon tetra chloride induced experimental animals were tested. Results: The ethanolic plant extract of both plant parts (leaves of LA and flowers of CT) were found to be effective against the carbon tetra chloride induced hepatotoxicity in experimental male albino rats. The results shows the elevated level of total protein, albumin, liver glycogen and reduced level of phosphatase, transaminase, lipid peroxide enzyme, and bilirubin than the carbon tetra chloride treated experimental animals. Conclusion: The leaves of Limonia acidisssima and flowers Clitoria ternatae has the efficacy to protect against hepato-toxic disease and hepatic necrosis may due to the presence of phyto-constituents present in it. Keywords: Limonia acidisssima, Clitoria ternatae, biochemical estimations, carbon tetra chloride