Serum Concentrations of Osteocalcin (OC) and Beta-Cross Laps (Beta-CTx) and Insulin Resistance in Morbid Obese Women with and without DM2

Aim: The present study was intended to establish the role of bone in grade III obese women with and without type 2 diabetes mellitus (T2DM). Material & Methods: Serum osteocalcin (OC), Beta Cross-Laps (Beta-CTx), parathormone (PTH) separar and y 25-hydroxyvitamin D (25OHD) concentrations were measured in 48 morbid obesity women (11 with T2DM and 37 control group). Insulin resistance and insulin secretion was assessed by measuring the HOMA-IR and the HOMAβ index and its association with OC and Beta-CTx. Results: Serum OC was significant lower in the diabetic group compared with non-diabetic patients 15.4 ± 3.6 ng/ml vs 22.1 ± 3.5 ng/ml, p<0.001 without significant differences in Beta-CTx (0.24 ± 0.1 vs 0.31 ± 0.2 ng/ml, ns). Both bone biomarkers, OC and Beta-CTx, showed a positive correlation (r=0.76; p<0.01) in the whole group subjects and in the control group (r=0.80, p<0.00), but no in the T2DM group (r=0.50, p ns). In the whole group of patients, OC correlated significantly with HOMA-IR (r=0.36; p<0.01) and HOMA-ß (r=0.36, p<0.01). Beta-CTx also correlated with HOMA-IR (r= 0.40, p<0.01) and HOMA-ß (r= 0.41, p<0.001. OC also significantly correlated with HOMA-IR (r=0.41, p