COMPARATIVE MODELLING OF TERTIARY STRUCTURES OF TWO VIRAL PROTEINS FROM BOMBYX MORI

The non-diapausing silkworm Bombyx mori is exploited both as a powerful biological model system and also as a tool to convert leaf protein into silk. Silkworm often suffers from viral infections causing heavy losses to the economy of the silk industry. One of the main virus pathogens is a nucleopolyhedrovirus, B. mori NPV (BmNPV). The present study is extended to Homology modelling of two important proteins- DNA-binding protein (DBP) and Late expression factor II (LEF-II) extracted from the UNIPROKB/SWISSPROT database. Further, the verified 3D structures were deposited to PMDB (PMDB Ids: PM0074795 and PM0074790) and concerned for characterization using structure and sequence based function prediction tools. The investigation will be helpful in understanding the molecular aspects of antiviral immunity in silkworm