VASCULAR ENDOTHELIAL DYSFUNCTIONS WITH HYPERLIPOPROTEINEMIA

Relevance. Cardiovascular diseases and, primarily coronary heart disease, remain among the leading causes of disability and mortality worldwide. Аim. To study the relationship between vascular endothelial dysfunction and hyperlipoproteinemia in experimental atherosclerosis. Materials and methods. The experiments were carried out on 28 Chinchilla rabbits with an average weight of 2.5-3.0 kg. The action of drugs was studied in dynamics: the initial 3-month condition and after one month of drug administration. The results obtained were compared with those of the control and intact groups. Results. Long-term administration of cholesterol is accompanied by the development of hypertriglyceridemia, the severity of which depends on the duration of the experiment. Conclusion. An important role in the development of endothelial dysfunction in hypercholesterolemia is played by a decrease in the synthesis of endothelial nitric oxide and an increase in its active radicals, causing modification of low-density lipoproteins and their deposition in the vascular endothelium