Synthesis and antibacterial evaluation of s-triazine based chalcones and their derivatives

Department of Chemistry, B. K. M. Science College, Valsad-396 001, Gujarat, India (Affiliated to The Veer Narmad South Gujarat University, Surat-395 007, Gujarat, India) E-mail : dranjani_solankee@yahoo.com Manuscript received 3 April 2008, revised 19 March 2009 .. accepted 31 March 2009 Various 2-(phenylamino/4' -substituted phenylamino)-4-(phenylamino/4' -substituted phenylamino)-6-[4' -{3" -(4"'- {2' -(5' -ethylpyridin-2' -yl)-ethoxy }-phenyl)-2"-propenon-1" -yl}-phenylamino]-s-triazine 6(a-e) were prepared by reaction of different ketones S(a-e) based on s-triazine nucleus and S-ethylpyridine-2-ethylether of 4-hydroxybenzaldehyde. Chalcones 6(a-e) on cyclisation with malanonitrile in the presence or ammonium acetate gave the corresponding cyanopyridines 7(a-e) and on cyclisation with hydroxylamine hydrochloride in the presence of alkali gave corresponding isoxazoles 8(a-e). The structures or cyanopyridine derivatives and isoxazole derivatives were confirmed from spectral data. All the synthesized compounds have been evaluated for their in vitro antibacterial activity against four different strains viz. S. aureus (MTCC-96), B. subtilis (MTCC-441) (Gram-positive bacteria) and E. coli (MTCC-443), S. paratyphi-B (MTCC-733) (Gram-negative bacteria) by agar diffusion method