Duality of P2X7 Receptor in Amyotrophic Lateral Sclerosis
- Volonté C
- Liguori F
- Amadio S
- Fabbrizio P
Publication date
July 2020
DOIAbstract
P2X7; SOD1-G93A mouse; amyotrophic lateral sclerosis; drug discovery; purinergic mechanism
P2X7; SOD1-G93A mouse; amyotrophic lateral sclerosis; drug discovery; purinergic mechanism
International audienceAbstract Amyotrophic lateral sclerosis (ALS) is a fatal motoneuron (MN) diseas...
The P2X7 receptor is a trimeric ion channel gated by extracellular adenosine 50-triphosphate. The re...
Neuroinflammation is one of the main physiopathological mechanisms of amyotrophic lateral sclerosis ...
The ATP-gated P2X7 ion channel has emerging roles in amyotrophic lateral sclerosis (ALS) progression...
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by selectiv...
Amyotrophic lateral sclerosis (ALS) is a disease with a resilient neuroinflammatory component caused...
In recent years there has been an increasing awareness of the role of P2X7, a receptor for extracell...
Mutant superoxide dismutase 1 (SOD1) can be constitutively released from motor neurons and transmitt...
Muscle weakness plays an important role in neuromuscular disorders comprising amyotrophic lateral sc...
The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not exclusively, o...
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disorder characterized by the degenerat...
Background Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease ch...
P2X7 is an adenosine 5’-triphosphate (ATP)-gated ion channel that plays many roles in health and dis...
International audienceExtracellular aggregates of amyloid β (Aβ) peptides, which are characteristic ...
International audienceAbstract Amyotrophic lateral sclerosis (ALS) is a fatal motoneuron (MN) diseas...
The P2X7 receptor is a trimeric ion channel gated by extracellular adenosine 50-triphosphate. The re...
Neuroinflammation is one of the main physiopathological mechanisms of amyotrophic lateral sclerosis ...
The ATP-gated P2X7 ion channel has emerging roles in amyotrophic lateral sclerosis (ALS) progression...
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by selectiv...
Amyotrophic lateral sclerosis (ALS) is a disease with a resilient neuroinflammatory component caused...
In recent years there has been an increasing awareness of the role of P2X7, a receptor for extracell...
Mutant superoxide dismutase 1 (SOD1) can be constitutively released from motor neurons and transmitt...
Muscle weakness plays an important role in neuromuscular disorders comprising amyotrophic lateral sc...
The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not exclusively, o...
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disorder characterized by the degenerat...
Background Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease ch...
P2X7 is an adenosine 5’-triphosphate (ATP)-gated ion channel that plays many roles in health and dis...
International audienceExtracellular aggregates of amyloid β (Aβ) peptides, which are characteristic ...
International audienceAbstract Amyotrophic lateral sclerosis (ALS) is a fatal motoneuron (MN) diseas...
The P2X7 receptor is a trimeric ion channel gated by extracellular adenosine 50-triphosphate. The re...
Neuroinflammation is one of the main physiopathological mechanisms of amyotrophic lateral sclerosis ...
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