FORMULATION AND CHARACTERIZATION OF BILAYERED BUCCAL TABLETS OF DIACEREIN

Buccoadhesive Bilayer buccal tablets of Diacerein were prepared by using Cashew nut tree gum, Xanthan gum and Karayagum as mucoadhesive polymers. Nine formulations were developed with varying concentrations of polymers F1 to F9 formulations were composed of Cashew nut tree gum, Xanthan gum and Karayagum in ratios of 1:1, 1:2 and 1:3. The formulated mucoadhesive buccal tablets were assessed for quality attributes like weight variation, hardness, thickness, friability, drug content, moisture absorption, surface pH and in vitro drug release studies. Optimized formulation F4 showed maximum release of the drug (99.59%). The FTIR results showed no evidence of interaction between the drug and polymers. All the evaluation parameters given the positive result and comply with the standards. The results indicated that the mucoadhesive buccal tablets of Diacerein may be good choice to bypass the extensive hepatic first pass metabolism with an improvement in bioavailability of Diacerein through buccal mucosa. Key words: Diacerein, Cashew nut tree gum, Xanthan gum and Karayagum and Buccal tablets