MODULATION OF GASTRO-INTESTINAL TRANSIT TIME BY FLOATING DRUG DELIVERY SYSTEM

Floating drug delivery system (FDDS) design appear to be one of the most effective and rational approaches for controlled oral drug delivery. The scientific and patent literature shows increased interest in academics and industrial research groups regarding the novel dosage forms that can be retained in the stomach for prolonged and predictable period of time. One of the most feasible approaches for achieving a prolonged and predictable dug delivery profiles in the gastrointestinal tract is to control the gastric residence time, using gastro retentive dosage forms that will provide us with new and important therapeutic options. From the formulation and technological point of view, the floating drug delivery system is considerably easy and logical approach. Floating drug delivery system enable prolonged and continuous input of the drug to the upper part of the gastro retention tract and improve the bioavailability of medication that is characterized by a narrow absorption window. An attempt has been made in this review article to introduce the readers to the current technological developments in floating drug delivery