Features of the intestinal microbiota functional status in early-aged children with rotavirus infection

Vorobiova N. V., Usachova O. V. Features of the intestinal microbiota functional status in early-aged children with rotavirus infection. Journal of Education, Health and Sport. 2021;11(10):157-172. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.10.014 https://apcz.umk.pl/JEHS/article/view/JEHS.2021.11.10.014 https://zenodo.org/record/5587771 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 30.09.2021. Revised: 12.10.2021. Accepted: 20.10.2021. Features of the intestinal microbiota functional status in early-aged children with rotavirus infection N. V. Vorobiova, O. V. Usachova Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine Vorobiova N. V., MD, PhD student of the Department of Pediatric Infectious Diseases, Zaporizhzhia State Medical University, Ukraine; ORCID ID: https://orcid.org/0000-0001-7610-8067; E-mail: Natahich19881988@gmail.com Usachova O. V., MD, PhD, DSc, Professor, Head of the Department of Pediatric Infectious Diseases, Zaporizhzhia State Medical University, Ukraine; ORCID ID: https://orcid.org/0000-0002-8413-027; E-mail: kdibzdmu@gmail.com Abstract The aim is to assess the intestinal microflora functional and structural disorders in early-aged children in the dynamics of rotavirus infection by studying intestinal metabolites in faeces – short-chain fatty acids (SCFA). Materials and methods. The study included 60 breastfed children aged 1-24 months with rotavirus infection (the study group) and 30 healthy children, representative by age and sex (the comparison group). Determination of SCFA (acetate, propionate, butyrate) in faeces was carried out in all children of the study group three times in the dynamics of the disease (on the 3rd, 5th and 10th day) and in healthy children once. Results. The total concentration of SCFA in children with rotavirus infection was 3 and 2.2 times lower than in healthy children in the acute period of the disease (p<0.01 on the 3rd and 5th day, respectively), increasing on the 10th day (p<0.05), however, not reaching the normal level (p<0.01). The decrease in the total pool of SCFA occurred due to all volatile acids (C2, C3, C4), the concentrations of which were lower than in healthy children (p