DESIGN AND EVALUATION OF EXTENDED RELEASE TRILAYERED MATRIX TABLETS OF SELEGILINE HCL

The present investigation was aimed for the formulation and evaluation of trilayer matrix tablets of Selegiline HCl used in the treatment of depression and in the therapy of Parkinson disease. Twenty seven formulations (F1-F27) for middle layer were prepared by direct compression method using 33 Response surface method (3 variables and 3 levels of polymers) by using Design of experiment software with natural polymers like Locust Bean Gum, Karaya, HPMC K 15M. The barrier layers was formulated employing hydrophobic swellable polymer natural wax i.e carnauba wax the swelling erosion modeling fillers which include water soluble Sodium CMC and EC. The procedure adopted to make the compacts was via direct compressions. The tablets were also evaluated for physicochemical characteristics and release kinetics. The physicochemical characteristics of the prepared tablets were satisfactory. The developed drug delivery systems showed prolonged drug release rates over a period of 24 h. The release profile of the optimized formulation (CF26) was described by the Zero-order and Higuchi model. These results also demonstrated the suitability of three-layered tablet formulation of Selegiline HCl to provide controlled release for prolonged period of time and improved linearity for Selegiline HCl in comparison to marketed product with conventional drug release profile in the management of Parkinson’s disease. Keywords: Selegiline HCl, Parkinson’s disease, Locust bean gum, Geomatrix