Severe beta-blocker overdose in a 65-year-old female

Marzęda Paweł, Kościuk Andrzej, Tchórz Michał. Severe beta-blocker overdose in a 65-year-old female. Journal of Education, Health and Sport. 2019;9(7):251-258. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3270413 http://ojs.ukw.edu.pl/index.php/johs/article/view/7127 https://pbn.nauka.gov.pl/sedno-webapp/works/917538 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 20.06.2019. Revised: 25.06.2019. Accepted: 06.07.2019. Severe beta-blocker overdose in a 65-year-old female Name Paweł Marzęda ORCID iD http://orcid.org/0000-0003-1697-5497 Affiliation Student’s Research Group in the Department of Toxicology, Medical University of Lublin Country Poland Principal contact for editorial correspondence. Name Andrzej Kościuk ORCID iD http://orcid.org/0000-0002-2853-7884 Affiliation Student’s Research Group in the Department of Toxicology, Medical University of Lublin Country Poland Name Michał Tchórz ORCID iD http://orcid.org/0000-0002-1308-099X Affiliation Department of Toxicology, Medical University of Lublin Country Poland Introduction: Population of people over 65 years old is one of the groups of the greatest risk of suicide attempt. In this age range the highest suicide rate that results in death is observed. Metabolism alterations and co-morbidities development with age may play major role in increasing suicide rate. Accidental and intentional drug over-ingestions are more common for people with numerous prescriptions and comorbid conditions. Overdose in such patients can pose great threat to patients life. Aim of the study: The purpose of this study is to depict course of β-adrenolitics and benzodiazpines poisoning on the base of case report. Materials and methods: The analysis of the patient's medical history and the review of available literature in the PubMed and Google Scholar databases. Results: The 65-year-old female, was brought by emergency medical services to the Toxicology Clinic due severe drug poisoning. Upon admission patient was unconscious, intubated, on ventilator, in overall severe condition. She presented symptoms of circulatory insufficiency. History revealed overdose of β-adrenolitics and benzodiazepines. The application of proper pharmacological treatment and heart pacing resulted in gradual improvement of patients condition. After one-week stay she was discharged home in good condition. Conclusions: Course of β-adrenolitics poisoning with addition of benzodiazepines poses great threat, especially when one suffers from numerous comorbidities. Therefore, due to wider availability of drugs and rising number of suicide attempts, as well as events of medication errors, it is crucial to be aware of elder people problems and prevent such situations. Key words: Betaadrenolitic; betablocker; bisoprolol; estazolam; overdos