ASSOCIATION BETWEEN PATTERNS OF BIO-CHEMICAL FACTORS AND BONE MARROW INFILTRATION AMONG PATIENTS PRESENT WITH NON-HODGKIN LYMPHONA

Objectives: This research work aimed to interrogate the pattern of involvement of bone marrow in the patients present with NHL (Non-Hodgkin’s Lymphoma) and to associate the pattern of β2-m (β2 microglobulin) & LD2 (Lactate Dehydrogenase-2) levels of these present patients. Methodology: this transverse research work carried out for a period of complete two years in General Hospital, Lahore. This research work carried out on fifty patients irrespective of gender and age separated into 2 groups i.e. Group-A containing twenty healthy controls whereas Group-B consisting thirty patients of non-Hodgkin lymphoma with the infiltration of bone marrow. We performed bilateral trephine biopsy of bone marrow to evaluate the patterns of infiltration of bone marrow. The determination of serum β2-m and LD-2 levels in already identified thirty patients of non-Hodgkin lymphoma. We compared these values with twenty healthy gender and age match controls. The determination of the correlation coefficients carried out with the utilization of the Pearson’s correlation coefficient. We made the estimations before the establishment of chemotherapy. Results: There was significant rise in the levels of β2-m and LD-2 (P-value < 0.050) in the patients of NHL with the advancement of disease as compared to the healthy controls. These markers of serology displayed negative correlation (-0.2350 for β2-m & -0.1330 for LD-2) with disease spread and involvement patterns in the patients of NHL. Conclusion: With the observation of patterns of involvement of bone marrow in the patients of NHL possible instruction about the treatment and prognosis protocols can be taken as the markers of serology levels associate with the disease spread an involvement pattern in NHL patients. Key Words: NHL, significant, association, correlation, bone marrow, determination, serum, chemotherapy