Synthesis and biological activity of some new 1,3-thiazolyl-6-bromoquinazolin-4(3H)ones

Department of Chemistry, Veer Narmad South Gujarat University, Surat-395 007, Gujarat, India E-mail : drnavin@satyam.net.in Manuscript received 15 December 2008, revised 11 June 2009, accepted 3 July 2009 The title compound 1,3-thiazolyl-6-bromoquinazolin-4(3H)ones 5t-xv have been synthesized from the molecule 2-[(2,6-dichlorophenyl)amino]phenyl acetic acid 1 through multi-step reaction sequence. The structures of new compounds have been confirmed by elemental analyses, IR, 1H and 13C NMR spectral data. All the compounds were evaluated for their in vitro antibacterial and antifungal activities