Effect of Englerina drummondii Balle ex Polhill & Wiens on Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH), Oestrogen, Progesterone on MSG Induced Alterations in Reproductive Parameters in Female Rats

Hormones are chemical substances that aid reproductive process and must be in normal proportion for fertility to take place. Hormones are important for both men and female reproductive process. Herbal medicine is been used across the globe to improve reproductive process. The aim of this study finds out the effect of Englerina drummondii Balle ex Polhill & Wiens on follicle-stimulating hormone (FSH), luteinizing hormone (LH), oestrogen, progesterone on MSG induced alterations in reproductive parameters in rats. The study involves a total of 45 female wistar rats weighing between 160g to 180g. The animals were randomly picked into 9 groups with 5 animals per group. Administration was as follows: Group 1(control) 5ml/kg of water, group 2 (MSG 800mg/kg), group 3 extract (100 mg/kg), group 4 extract (200 mg/kg), group 5 extract (400 mg/kg), group 6 extract (100 mg/kg + MSG 800 mg/kg), group 7 (200 mg/kg + MSG 800mg/kg), group 8 (400mg/kg + MSG 800mg/kg) and group 9 (letrozole 0.6mg/kg + MSG 800mg/kg). Administration of extract was done through oral gavage for 28 days, thereafter, the animals were sacrificed on the 29th days, then blood samples were collected for hormonal analysis. The results shows that extract of Englerina drummondii Balle ex Polhill & Wiens leaves significantly increased the serum level of gonadotropic hormones (FSH, LH) and significantly decreased the serum level of sex hormones (progesterone and estradiol). The statistical analysis was carried out using Statistical Package for Social Science (SPSS) version 23