Possibility of therapy of acute ischemic stroke by polyphenols of flavonoid group

Dobrovolskyi V. V., Stoyanov O. M., Mashchenko S. S. Possibility of therapy of acute ischemic stroke by polyphenols of flavonoid group. Journal of Education, Health and Sport. 2019;9(1):388-395. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2579346 http://ojs.ukw.edu.pl/index.php/johs/article/view/6639 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 03.01.2019. Revised: 11.01.2019. Accepted: 31.01.2019. POSSIBILITY OF THERAPY OF ACUTE ISCHEMIC STROKE BY POLYPHENOLS OF FLAVONOID GROUP V. V. Dobrovolskyi, O. M. Stoyanov, S. S. Mashchenko Department of Neurology, Odessa National Medical University, Odessa, Ukraine Abstract Objective - to study neuroprotective effect of Quercetin in ischemia-reperfusion injury in acute ischemic stroke. Materials and methods. The study included 98 patients with acute ischemic stroke. All patients: main and control group, received standard treatment in accordance with the clinical protocol order Ministry of Health of Ukraine from 03.08.2012, № 602. Patients of the main group (n=68) on the back of the base further treatment was administered quercetin (Corvitin lyophilisate injection solution) course of 10 days according to the scheme: 500 mg of the drug diluted in 100 ml of 0.9% of the physiological solution intravenously twice a day for the first five days and once a day for the next five days. Patients in the control group (n=30) - quercetin is not appointed. Assessment by GCS, NIHSS, Barthel served in the 1st, 3rd, 5th, 10th day of the disease. Results. Simultaneously with the standard treatment, intravenous administration of quercetin, positively influenced the regression of focal neurological symptoms on the NIHSS and Barthel scales in patients with acute ischemic stroke, increased the proportion of patients in the consciousness or with its minor impairments in the GCS, ie contributed to an earlier “awakening” in acute ischemic stroke. Conclusions. Neuroprotective effect of quercetin (Corvitin lyophilisate injection solution) can be explained by its polytropic, antioxidant, anti-inflammatory, membrane-stabilizing effect in ischemia-reperfusion. Keywords: stroke, reperfusion injury, quercetin