Integrated Modular Model Linking Metabolism, Signaling Transduction and Gene Expression Regulation in Human Skeletal Muscle

Exercised-induced adaption of skeletal muscle to aerobic endurance training is ensured by instant activation of signaling transduction pathways in the muscle cells with consequent alteration of both metabolic fluxes and expression for a versatile group of genes. Despite the experimentally based efforts to disentangle the complexity of the muscle adaptation process caused by multiple interactions and intersections on signaling, metabolic and gene expression levels, the quantitative and mechanistic contribution of each component of the signaling cascades on downstream genetic regulation processes has not been fully elucidated. Data-driven mathematical models provide a rigorous way to analyze and understand such intricate biological systems. Herein a novel mathematical model linking anaerobic and aerobic metabolism, Ca2+ -dependent signaling pathway and downstream transcription regulation of early and late response genes in human skeletal muscle during and after acute exercise developed in BioUML platform has been presented.http://ceur-ws.org/Vol-2569/short1.pd