HYPERURICEMIA: PHYSIOLOGY, CLINICAL PRESENTATION AND PHARMACOLOGICAL MANAGEMENT; A PRACTICE BASED STUDY FROM HYDERABAD, SINDH, PAKISTAN.

The frequency of hyperuricemia patients is increasing in the clinical practice especially the arthralgia cause being the changing life style probably. Uric acid a normal end product of purine metabolism gets accumulated in joints following rise in plasma concentration either due to excessive production or reduced excretion. This results into gouty arthritis, hypertension, renal stones requiring dual management with dietary restriction and pharmacological intervention. The current observational research study was carried out in Orthopedic Consultant clinic and Liaquat University of medical and health sciences. Serum uric was measured in 374 Patients selected through non-probability consecutive sampling using device method at consult clinic. SPSS 22nd version and t-test was used for data analysis, mean serum uric acid of the population was 5.01mg/dl however hyperuricemia was seen in 10.91%(41) while 89.09%(333) were having normal range. Minimum uric acid was 1.3mg/dl in the study population while maximum was noted as 13.20mg/dl. The mean serum uric acid in male group was 5.23+1.31mg/dl while it was female 4.70+1.76mg/dl in female group of patients and the difference was significant statistically (p-0.005) Conclusion: Hyperuricemia is found in almost 11% of study subjects while and there exists significant difference between the two genders. Keywords: Gout, Uric Acid, hyperuricemia, Arthralgia