ASSOCIATION OF IL-17A POLYMORPHISMS IN TYPE-2 DIABETES WITH CHRONIC PERIODONTITIS PATIENTS

ntroduction: The association of genetic polymorphisms with periodontitis has been studied extensively. The IL-17 is a group of cytokines which comprises six different molecules (IL-17A, B, C, D, E & F). Among these IL-17A & F are the most commonly understood cytokine which plays a critical role in inflammatory diseases and periodontal inflammation. Objective: To evaluate whether Interleukin -17A gene polymorphism has any influence on the development of periodontitis in type 2 diabetes patients. Materials and Methods The study was carried out in 60 subjects and consists of 4 groups which included, Group A: 15 Type 2 diabetes patients with chronic periodontitis, Group B: Type 2 diabetes patients without periodontitis, Group C: 15 Nondiabetic patients with periodontitis, Group D: Nondiabetic patients without periodontitis. Blood samples were drawn from the subjects and analyzed for IL-17A polymorphism by using the conventional polymerase chain reaction method. Results: No statistically significant differences seen in the genotype distribution among chronic periodontitis patients with or without diabetes and healthy controls. The odds ratio indicated that increased risks for CP were associated with the rs2275913 allele (IL-17A) in patients with or without diabetes. This allele was correlated with worse clinical parameters of chronic periodontitis in diabetes patients. Conclusion: These results showed that the IL-17A (rs2275913) polymorphism is associated with increased risk for chronic periodontitis in type 2 diabetes patients