FORMULATION AND EVALUATION OF CIMETIDINE PRESS COATED TABLETS FOR CHRONOTHERAPEUTIC DRUG DELIVERY

Since early times daily rhythms in plants and animals have been observed. The leaves of certain plants opened during day and closed at night, showing a clear rhythmicity. Circadian rhythms of behaviour in mammals are known to be robust and precise. The efficacy and toxicity of many drugs vary depending upon the relationship between the dosing schedule and the 24 hour rhythms of biochemical, physiological and behavioural processes. Also several drugs cause alterations to 24 hours rhythms leading to illness and altered homeostatic regulation. The alteration of biological rhythm is a new concept of adverse effects, which can be minimized by optimizing the dosing schedule.They are predictable resonating dynamic systems whom require different amounts of drug at predictably different time within circadian cycle which will maximize desired and minimize undesired drug effects.The aim of the work was to prepare and evaluate of cimetidine press coated tablets for chronotherapeutic drug delivery. Keywords: Cimetidine, Press coating , Chronotherapeutic, Drug Deliver