Analysis of drug ofloxacin in bulk and single component pharmaceutical tablets by non-aqueous potentiometric titration method

Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola-444 001, Maharashtra, India E-mail: pradip222091@yahoo.co.in Manuscript received 05 March 2018, accepted 04 April 2018 Analysis of drug ofloxacin in bulk and single component pharmaceutical tablets has been carried out by non-aqueous potentiometric titration method using isopropyl alcohol as the solvent and KOH in isopropyl alcohol as the titrant. The effect of solvent and concentration on potentiometric analysis of drug ofloxacin as well as its analysis in bulk and single component pharmaceutical tablets has been studied by using a pair of glass and calomel electrode. The method was found to be quite simple, efficient, precise and gave results comparable to those obtained by Indian Pharmacopoeia (I.P.) method