FORMULATION AND DEVELOPMENT OF ORAL DISSOLVING FILMS OF BUMETANIDE

Objective: Formulation and Development of oral dissolving Films of Bumetanide. Materials and methods: BUMETANIDE, HPMC E-50, HPMC E-5, HPMC E-3, PE, 4000 (Flakes) and Aspartame. Citric Acid could be formulated with low viscosity film formers viz. HPMC E50 in combination with HPMC E5, E15. Bumetanide could be successfully incorporated in FDFs with of the above polymers and polyethylene glycol 4000 is used as a plasticizer. PEG 4000 itself has a solubulizing affect and result in faster dissolution. Hence, there is no need of superdisintegrants. Use of low viscosity grade HPMC polymers resulted in giving films with transparent and smooth texture. Conclusion: Among all the developed formulations, F9 formulation formulated with HPMC E15 and HPMC E50 in the ratio of 1:1 showed good in vitro disintegration time and dissolution profile. Key words: Bumetanide, PEG, HPM