MORPHOLOGICAL CHANGES IN THE RAT KIDNEYS INFLUENCED BY SURFACTANT

Popova T. M. MORPHOLOGICAL CHANGES IN THE RAT KIDNEYS INFLUENCED BY SURFACTANT. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2019;2(56):145-150. ISSN 1818-9385 DOI http://dx.doi.org/10.5281/zenodo.3251018 http://aptm.org.ua УДК 611.61-018: 612.46:615.099 MORPHOLOGICAL CHANGES IN THE RAT KIDNEYS INFLUENCED BY SURFACTANT T. M. Popova Kharkiv National Medical University, Kharkiv, Ukraine e-mail: popovatatyanamikh@gmail.com Summary The present study is focused on elucidate the effect of Laprol-604 on morphological structure of rat kidneys. The model of intoxication was produced by oral administration of water solution Laprol-604 to rats of experimental I group. The pathomorphological changes in the kidneys I group have been found. Atrophy of glomerular cells, Bowmens’ capsular spaces have been extended; tubular epithelial cells have been degenerated. In addition, protein in the renal tubular lumen and interstitial edema have been detected. These morphological changes in the kidneys I group indicate significant load renal tissue. Keywords: kidney, Laprol-604, surfactant, polyol