Biomarkers of pro- and antioxidant systems in guinea pigs' blood in late periods of experimental allergic alveolitis development and their correction with thiotriazolin

Fyrduchco – Regeda Mariana Mukchailivna, Solvar Zoryana Ljubomurivna, Baida Mariana Ljubomurivna. Biomarkers of pro- and antioxidant systems in guinea pigs’ blood in late periods of experimental allergic alveolitis development and their correction with thiotriazolin. Journal of Education, Health and Sport. 2017;7(2):732-737. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1181868 http://ojs.ukw.edu.pl/index.php/johs/article/view/5297 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.02.2017. Revised 24.02.2017. Accepted: 27.02.2017. BIOMARKERS OF PRO- AND ANTIOXIDANT SYSTEMS in guinea pigs’ blood in late periods of experimental allergic alveolitis development and their correction with thiotriazolin Mariana Mukchailivna Fyrduchco – Regeda1, Zoryana Ljubomurivna Solvar 2 Mariana Ljubomurivna Baida3 Danylo Halytsky Lviv National Medical University 1 Department of pathological physiology, PhD 2 Department of pathological physiology, postgraduate student 3 Department of pathological physiology, PhD, Assistant Professor Lviv, Ukraine Abstract Hypersensitivity pneumonitis is a potentially fatal immunological lung disease caused by occupational or environmental exposure to specific antigens and resulting from lymphocytic and frequently granulomatous inflammation of the peripheral airways, alveoli, and surrounding interstitial tissue which develops as the result of a non-IgE-mediated allergic reaction to a variety of organic materials or low molecular weight agents that are present in the workplace. The offending agents can be classified into six broad categories that include bacteria, fungi, animal proteins, plant proteins.The cornerstone of treatment is early removal from exposure to the eliciting antigen, although the disease may show an adverse outcome even after avoidance of exposure to the causal agent. The primary insults cause the greatest production of reative oxygen species, which contributes to oxidative damage by attacking all macromolecules, including lipids, proteins and nucleic acids, leading to defects in their physiological function. Key words: experimental allergic alveolitis, free radicals, superoxyde dismutase, thiotriazolin