EVALUATION OF LIPID PEROXIDATION AND BIOCHEMICAL RESPONSE IN OVARIAN CANCER PATIENTS: A PERSPECTIVE STUDY FROM LOCAL POPULATION OF LAHORE-PAKISTAN

Background: Ovarian cancer refers to the growth of any cancerous cells in the ovaries. Most often ovarian cancer arises from the epithelium (outer lining) of the ovary. Ovarian cancer considered as the major reason of death in gynecological malignancies. The ovaries are two small organs located on either side of the uterus in a woman’s body. Methodology: 5.0 ml blood sample of 50 ovarian cancer patients and 50 healthy persons was collected in EDTA vials from oncology department of Mayo and Jinnah Hospital Lahore. MDA, CAT, GSH, SOD, Micronutrients, serum Electrolytes were estimated Results: Serum MDA level in ovarian malignancy patients is remarkably inflated (8.42 ± 0.53) whereas there level in healthy individuals was extremely low (2.25±.24). In patients the level of GSH reduced (0.12 ±0.14) as compared to normal individual (6.35 ± 0.17). The CAT level is moderately decreased in patients (0.60±0.52) as compared to healthy individual is high (4.16±1.06). Ovarian cancer patients have remarkably deficient vitamin A level (2 .55±0.17) while its level was extremely high in healthy subjects (7.15±0.47). So it depicts that ovarian cancer patients shows the highly significant behavior (p꞊0.000).Conclusion: A fine balance between oxidants (ROS production) and antioxidants is predominant for the general defensive capacity of cells in contrast to oxidative damage. MDA level in ovarian malignancy patients is remarkably inflated due to high lipid peroxidation mechanism. Key Words: SOD, MDA, GSH, CAT, Ovarian Cancer