CURRENT ANTIMICROBIAL THERAPY OF INFECTIOUS COMPLICATIONS OF GENITOURINARY SYNDROME IN PERIMENOPAUSAL WOMEN

Genitourinary menopausal syndrome is characterized by urogenital and sexual symptoms (vaginal dryness and itching, urinary incontinence, dyspareunia, anorgasmia). According to many experts, the symptoms of genitourinary menopausal syndrome require special attention, since women are often silent and do not complain about its manifestations. Purpose of the study. Treatment optimization of vulvar and vaginal atrophic changes that associated with estrogen deficiency in perimenopausal women. Materials and methods. 41 women with infectious complications of genitourinary menopausal syndrome were examined and treated. The structure of this syndrome in examined women was dominated by symptoms of vulvovaginal atrophy (itching, burning, irritation), dysuria, impaired sexual function and quality of life in general. A study of sensations state of women before and after treatment was carried out using the Barlow scale and vaginal health index. All participants were prescribed a topical preparation containing nifuratel and nystatin in vaginal cream as a mototherapy for 8 days. The choice of the nifuratel drug in perimenopausal women is associated with its wide spectrum of its antimicrobial activity and a convenient form of use (cream is the most attractive form with the prevalence of atrophic processes and irritation of the mucous membrane). Antifungal effect of nystatin has an additional therapeutic effect in women with vaginal candidiasis. Study results. Participants showed a significant regression of pathological symptoms and a significant improvement in the life quality after treatment, as evidenced by a significant improvement in the Barlow score by 2.6 times. It should be noted that the positive therapeutic effect persisted for a month after completion of therapy. Conclusions. Based on the study results it can be concluded that the cream containing nifuratel and nystatin is highly clinically effective for treating infectious complications of genitourinary syndrome in perimenopausal women, that makes it possible to recommend this drug in case of such pathological menopausal disorders