A CROSS-SECTIONAL STUDY TO DETERMINE THE FREQUENCY OF FACTORS LEADING TO METABOLIC SYNDROME AMONG NON -ALCOHOLIC FATTY LIVER DISEASE (NAFLD)

Objective: To determine the frequency of factors leading to metabolic syndrome among non -alcoholic fatty liver disease (NAFLD) patients at a tertiary care hospital. Study Design: Descriptive cross-sectional study. Place and Duration of Study: Department of Medicine, Holy Family Hospital, Rawalpindi. Study was carried out over a period of one year from August, 2018 to July, 2019. Material and Methods: A total of 110 patients were included in this study. History was taken to rule out alcohol intake, viral and drug induce d etiology, to determine the presence of co -morbidities like obesity, type 2 diabetes mellitus, arterial hypertension and dyslipidemia. Physical examination was carried to determine the arterial blood pressure and to determine anthropometric data that is weight, height, body mass index (BMI) and abdominal obesity by measuring waist circumference. Results: Mean age of the patients was 49.95 ± 8.86 years. There were 72 male patients (65.5%) while 38 (34.5 %) patients were female. Different metabolic factors were central obesity in 82 patients (74.5%), raised high density lipoprotein (HDL) in 19 patients (17.3%), raised cholesterol in 87 patients (79.1%), raised blood pressure in 65 patients (59.1%) and raised fasting plasma glucose in 82 patients (74.5%). Mean BMI was 26.31 kg/ m 2 ± 2.68, mean waist circumference was 109.82 cm ± 18.41, mean cholesterol was 237.50 ± 48.47mg/ dl , mean systolic blood pressure was 148.88 mmHg ± 22.10, mean diastolic blood pressure was 90.41mmHg ± 12.25 and mean fasting plasma glucose was 113.28mg/ dl ± 22.80. Stratification regarding age was carried out. Conclusion: A considerable number of patients with NAFLD had metabolic syndrome. There was a close correlation between NAFLD and metabolic syndrome. Keywords: IDF criteria, Metabolic syndrome, Non-alcoholic fatty liver disease