AMELIORATIORATING ROLE OF LYCOPENE AND TOMATO PASTE (WITH PEEL) ON GENERAL HEALTHAND LIVER HISTOPATHOLOGY OF FLOURIDE EXPOSED SWISSALBINO MICE

Present communication deals with ameliorating role of 2 diet supplements viz. lycopene and tomato paste with peel on general health and liver histopathology of Swiss albino mice exposed to sub-acute dose of fluoride (190 mg/kg body wt. prepared by dissolving sodium fluoride (Merck Ltd., Mumbai, India) in distilled water) for 7days. Their recovery was also monitored after 48days offluoride with drawl. The visible toxic effects of fluoride were observed on fur (less hairy & lustreless) and nails (black) ofmice fed on standard diet were absent in the diet supplement groups. Fluoride exposure distorted hepatocytes and dilated sinusoids, portal and central veins in liver, particularly in the standard feed group. Fluoride with drawl led to better recovery of general health and liver histology in the diet supplement groups