Zwitterionic polysaccharides of Shigella sonnei: synthetic study towards a ready-for-oligomerization building block made of two rare aminosugars

Shigellosis is an endemic diarrheal disease caused by Gram-negative bacteria named Shigella. The most exposed polysaccharides of Shigella sonnei display a zwitterionic disaccharide repeating unit (AB) made of two rare aminosugars: [4)-α-l-AltpNAcA-(1®3)-β-d-FucpNAc4N-(1®]. An original synthesis of a ready-for-oligomerization AB disaccharide is reported