AMELIORATION OF ALTERED ANTIOXIDANTS STATUS BY GINGER IN STZ INDUCED DIABETIC RAT BRAIN

The present study was carried out to investigate the protective effect of Ginger on lipid peroxidation (LPO), antioxidants activities of both enzymatic and non-enzymatic in streptozotocin (STZ)-induced diabetic rats brain. Thirty Wistar strain rats were divided into five equal groups: Normal control (NC), Diabetic control (DC), Ginger treated (Gt), and Diabetic plus ginger treated (DC + Gt) and Diabetic plus glibenclamide (Standered reference drug). Experimental diabetes was induced by a single dose of STZ (50mg/kg, i.p.) injection. The oxidative stress was measured by tissue Lipid peroxidation (LPO) level, content of reduced glutathione (GSH) and by antioxidant enzymatic activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) in rat brain. We observed in the present study antioxidant enzymatic activities and glutathione content were decreased in diabetic control rats. Administration of Ginger (200mg/kg day) diabetic rats showed significant increase in the activities antioxidant enzymes when compared to diabetic control rats. From the present results, we conclude that diabetes-induced brain oxidative stress was modulates by ginger treatment, thus ginger can be used as a regular nutrient to care for the brain tissue