Chronic sleep deprivation increase the risk of Alzheimer's disease

Szabat Przemysław, Poleszak Julita, Piwoński Michał, Kozyra Magdalena, Wiśniewski Karol, Milanowska Joanna. Chronic sleep deprivation increase the risk of Alzheimer's disease. Journal of Education, Health and Sport. 2019;9(3):135-145. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2589487 http://ojs.ukw.edu.pl/index.php/johs/article/view/6662 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eissn 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.02.2019. Revised: 15.02.2019. Accepted: 10.03.2019. Chronic sleep deprivation increase the risk of Alzheimer's disease Przemysław Szabat1, Julita Poleszak1*, Michał Piwoński1, Magdalena Kozyra1, Karol Wiśniewski1, Joanna Milanowska2 (1) Student Research Group of Applied Psychology, Medical University of Lublin (2) Department of Applied Psychology, Medical University of Lublin *Address for correspodence: Duleby 17, 20-357 Lublin, telephone number: 535305586, e-mail address: julita.poleszak@wp.pl ORCID ID: Przemysław Szabat https://orcid.org/0000-0001-5796-1900 Julita Poleszak https://orcid.org/0000-0002-5166-6262 Michał Piwoński https://orcid.org/0000-0001-6510-8993 Magdalena Kozyra https://orcid.org/0000-0002-0260-4102 Karol Wiśniewski https://orcid.org/0000-0001-8312-2529 Joanna Milanowska https://orcid.org/0000-0001-9741-1583 Introduction: Sleep deprivation is a common phenomenon among modern society. Due to the fact that many people are chronically sleepless, the possible negative consequences of sleep disorders for health should be investigated. The aim of the study: The aim of this article is to analyze the studies linking sleep disorders with changes in β-amyloid levels and the development of Alzheimer's disease. Material and method: Standard criteria were used to review the literature data. A search of articles in English was carried out in the PubMed and Google Scholar database. Description of the state of knowledge: The studies described show that sleep deprivation increases the level of βA in cerebrospinal fluid (CSF) in humans. This suggests that chronic sleep disturbances may contribute to the formation of amyloid plaques and other pathologies found in AD, which leads to an increased risk of this disease. Summary: The data confirms that sleep provides an important function in maintaining the metabolic homeostasis of neurons, and sleep deprivation significantly raises the level of βA in CSF. However, we still can not tell if a night with sufficiently long sleep can negate the accumulation of β-amyloid caused by poor nocturnal sleep, but this is undoubtedly the direction to be investigated in future years. Keywords: Sleep deprivation, Alzheimer's disease, dementi