Features changes phagocytic activity of leukocytes in development of peptic ulcer under pneumonia

Furdychko L. О. Features changes phagocytic activity of leukocytes in development of peptic ulcer under pneumonia. Journal of Education, Health and Sport. 2017;7(5):723-730. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.819492 http://ojs.ukw.edu.pl/index.php/johs/article/view/4568 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.05.2017. Revised: 23.05.2017. Accepted: 31.05.2017. FEATURES CHANGES PHAGOCYTIC ACTIVITY OF LEUKOCYTES IN DEVELOPMENT OF PEPTIC ULCER UNDER PNEUMONIA L. О. Furdychko Danylo Galitsky Lviv National Medical University Absract Pneumonia remains the global and urgent medical and social problem. Among the most common diseases are the cause of death from infectious diseases and leads to economic losses throughout the world regardless of their level of development. As we know, based on the origin and progression of pneumonia in pathogenetic perspective, with a variety of biologically active substances, products of lipid peroxidation, inflammation, etc. components, and prolonged use of a drug substance can lead to comorbidity. For the experiment, we selected two models of disease: experimental pneumonia (EP) and peptic ulcer (PU). Currently, promising to study the role nonspecific resistance in the pathogenesis of these pathologies. Factors nonspecific reactivity are important in the immune defense of the body. Materials and methods. The study was conducted on 39 male guinea pigs. The experimental pneumonia caused by the method Shlyapnykova V. N., Solodova T. L., gastric ulcer simulated method Komarov V. I. Nonspecific resistance of animals we evaluated, examining the phagocytic activity of leukocytes (FAL), nitroblue tetrazolium test (NST- test). Phagocytic activity of leukocytes (FAL) in blood were studied in terms phagocytic index (FI) and the phagocytic number (SF) and determined by the method Menshikov V. V. NST - test method Vyksmana M. E., Mayanskoho A. H. The figures research results processed by statistical method Student. Results and discussion. Found that the 4- th day after simulation pneumonia and gastric ulcer occurred a gradual increase in phagocytic index by 39.5% (P <0.05) in relation to the same figure intact group of porpoises. Then on the 8-th day of disease models showed a significant increase in FI - 72, 8% compared to the 1st group of animals. On the 4-th day and EP at PU was found a significant increase in the number of phagocytic levels by 43.6% (P <0.05) compared with controls. After 8 days the EP and PU it was a further increase of 76.9% (P <0.05). The results showed that at 4 days of experimental NST diseases without stimulating increased by 51.2% (P <0.05) compared with control values, and only 8 per day PU at EP and its significant increase of 81.8 % (P