Synthesis of 2'-(substituted)benzylidene hydrazino-5-arylamino-1,3,4-thiadiazoles and their antimicrobial activity

P.G. Department of Chemistry, Shn Shivaji Science College, Amravati-444 603, Maharashtra, lnd1a Manuscript received 26 May 2005, revised 11 October 2006, accepted 3 November 2006 Several 2' -(substituted) benzylidene hydrazino-S-arIamino-1,3,4-thiadiazoles (5a-m) have been synthesized by the condensation of 1-(N-aryl thioamido)thiocarbohydrazides (3a-f) and different aromatic aldehydes in benzene medium, followed by intramolecular cyclization or compounds (4a-m) in renuxing ethanol medium. The former in turn have been prepared by the reaction of aryl isothiocynates (2a-f) and thiocarbohydrazide (1). Compounds (Sa-m) on brominationwith bromine in glacial acetic acid afforded dibromo derivatives (6a-m). The synthesized compounds were assayed for their antimicrobial activity against gram positive as well as gram negative micro-organisms