Determination and quantification of piroxicam in tablets by RP-HPLC

Department of Chemistry, University of Karachi, Karachi-75270, Pakistan E-mail : arayne@gawab.com Fax : 92-21-4812699 & 9243173 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan Manuscript received 16 November 2004, revised 5 April 2005, accepted 20 June 2005 A simple and rapid high-performance liquid chromatographic (HPLC) method for the determination and quantification of piroxicam has been developed and validated; meloxicam was used as internal standard. Methanol/water (70 : 30, v/v) was used as mobile phase, with flow rate 2 ml/min. pH was adjusted to 2.6 with phosphoric acid. UV detection was performed at 230 nm. Recovery of piroxicam (in Feldene Flash 20 mg tablets) was from 99.49 to 100.29%