Background: The manipulation of dendritic cells (DCs) for cancer vaccination has not reached its full potential, despite the revolution in cancer immunotherapy. DCs are fundamental for CD8+ T cell activation, which relies on cross-presentation of exogenous antigen on MHC-I and can be fostered by immunogenic cancer cell death. Translational and clinical research has focused on in vitro-generated monocyte-derived DCs, while the vaccination efficacy of natural conventional type 1 DCs (cDC1s), which are associated with improved anti-tumor immunity and specialize on antigen cross-presentation, remains unknown.Methods: We isolated primary spleen mouse cDC1s and established a protocol for fast ex vivo activation and antigen-loading with lysates of...
Dendritic cells (DCs), as professional antigen-presenting cells (APCs), play a key role in the initi...
Decreased antigen presentation contributes to the ability of cancer cells to evade the immune system...
Background: Cancer as the uncontrolled proliferation and spread of transformed cells is one of the l...
Background: The manipulation of dendritic cells (DCs) for cancer vaccination has not reached its ful...
International audienceDendritic cells (DCs) are endowed with a unique potency to prime T cells, as w...
BackgroundType 1 conventional dendritic cells (cDC1s) possess efficient antigen presentation and cro...
Dendritic cells (DC) are able to elicit anti-tumoral CD8+ T cell responses by cross-presenting exoge...
Dendritic cells (DCs) are potent professional antigen-presenting cells (APC) capable of inducing the...
Dendritic cells (DC) pulsed with tumor-derived antigenic material have widely been used in antitumor...
IntroductionAn important hallmark of cancer is escaping the immune system. Despite advances in immun...
Abstract Dendritic cells (DCs) are professional antigen-presenting cells that are integral to the in...
Dendritic cells (DCs) are endowed with a unique potency to prime T cells, as well as to orchestrate ...
Grimshaw MJ, Papazisis K, Picco G, et al. Immunisation with 'naive' syngeneic dendritic cells protec...
Immunotherapeutic strategies to stimulate anti-tumor immunity are promising approaches for cancer tr...
IntroductionPriming of tumor-specific T cells is a key to antitumor immune response and inflammation...
Dendritic cells (DCs), as professional antigen-presenting cells (APCs), play a key role in the initi...
Decreased antigen presentation contributes to the ability of cancer cells to evade the immune system...
Background: Cancer as the uncontrolled proliferation and spread of transformed cells is one of the l...
Background: The manipulation of dendritic cells (DCs) for cancer vaccination has not reached its ful...
International audienceDendritic cells (DCs) are endowed with a unique potency to prime T cells, as w...
BackgroundType 1 conventional dendritic cells (cDC1s) possess efficient antigen presentation and cro...
Dendritic cells (DC) are able to elicit anti-tumoral CD8+ T cell responses by cross-presenting exoge...
Dendritic cells (DCs) are potent professional antigen-presenting cells (APC) capable of inducing the...
Dendritic cells (DC) pulsed with tumor-derived antigenic material have widely been used in antitumor...
IntroductionAn important hallmark of cancer is escaping the immune system. Despite advances in immun...
Abstract Dendritic cells (DCs) are professional antigen-presenting cells that are integral to the in...
Dendritic cells (DCs) are endowed with a unique potency to prime T cells, as well as to orchestrate ...
Grimshaw MJ, Papazisis K, Picco G, et al. Immunisation with 'naive' syngeneic dendritic cells protec...
Immunotherapeutic strategies to stimulate anti-tumor immunity are promising approaches for cancer tr...
IntroductionPriming of tumor-specific T cells is a key to antitumor immune response and inflammation...
Dendritic cells (DCs), as professional antigen-presenting cells (APCs), play a key role in the initi...
Decreased antigen presentation contributes to the ability of cancer cells to evade the immune system...
Background: Cancer as the uncontrolled proliferation and spread of transformed cells is one of the l...