A REVIEW ON SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM OF POORLY WATER SOLUBLE

Lipid-based drug delivery systems are extensively reported in the literature for enhancing drug solubility, permeability, and bioavailability. These systems include simple oil solutions, coarse, multiple, and dry emulsions, complex self-emulsifying, micro emulsifying, or nano emulsifying drug delivery systems. Self-emulsifying systems, further classified as self-micro emulsifying drug delivery systems (SMEDDS) and self-nano emulsifying drug delivery systems (SNEDDS), are the most prevailing and commercially viable oil-based approach for drugs that exhibit low dissolution rate and inadequate absorption. Ever since the progress of SNEDDS, they drew the interest of researchers in order to deal with the challenges of poorly water-soluble drugs. SNEDDS is a proven method for enhancing the solubility and bioavailability of lipophilic compounds. Considering the ease of large-scale production and the robustness of SNEDDS, several formulations techniques are commercially available. The stability of SNEDDS can be further enhanced by solidifying liquid SNEDDS. Controlled release and supersaturated SNEDDS received patient compliance with larger drug loading. The presence of biodegradable ingredients and "drug-targeting opportunities" facilitate SNEDDS' clear merit and distinction amongst available solubility enhancement techniques. In this article, an attempt was made to present an overview of SNEDDS, their mechanism, formulation excipients, and potentials of SNEDDS, recent advancements, advantages, and disadvantages of SNEDDS formulations. The article also focuses on reviewing the application of SNEDDS in enhancing the bioavailability of antihypertensive drug. KEYWORDS: Self nanoemulsifying drug delivery system; SNEDDS; Rosuvastatin calcium; solubility study, Ternary Phase Diagram